Determination of pKa values of active pharmaceutical ingredients
نویسندگان
چکیده
The acid dissociation constant is an important physicochemical parameter of a substance, and knowledge of it is of fundamental importance in a wide range of applications and research areas. We present a critical review of published methods and approaches for the determination of acid dissociation constants, with a special emphasis on the pKa values of active pharmaceutical ingredients. a 2007 Elsevier Ltd. All rights reserved.
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